📄 Category

pharmacology and toxicology

107 papers

Investigation of sterile hydrogels as topical vehicles for APOSEC™, a stressed peripheral blood mononuclear cell secretome for the treatment of poorly healing wounds

This study developed and evaluated a sterile, autoclavable hydrogel (APOgel) for the topical delivery of APOSEC™, demonstrating that while terminal sterilization enhanced drug release, the current syringe-mixing process requires optimization to ensure uniform distribution of active ingredients despite maintaining overall wound-healing efficacy.

Hamid, D., Auer, L., Mohr, S. + 12 more2026-02-28📄 pharmacology and toxicology

A General Analytic Approach to Predicting the Best Antibiotic Dosing Regimen

This paper employs mathematical modeling to demonstrate that the concavity of an antibiotic's dose-response curve is the critical factor in determining whether constant low-dose or repeated high-dose regimens are optimal for specific antibiotic-bacteria pairings, thereby challenging the universal "hit hard and hit early" approach to combat antimicrobial resistance.

Childers, L., Abel zur Wiesch, P., Conway, J. M.2026-02-26📄 pharmacology and toxicology

Short-Term Performance Assay Identifies Functional Benefits and Early Toxicity of Longevity Interventions in Mice

This study presents a short-term, multi-parametric performance assay that rapidly identifies functional benefits and early toxicity of five candidate longevity interventions in mice, while also marking the first comprehensive preclinical aging research fully funded through tokenized decentralized science (DeSci).

Marin-Jerez, E., Rueda-Carrasco, J., Melendez-Rodriguez, F. + 4 more2026-02-26📄 pharmacology and toxicology

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

This study demonstrates that inhibiting EZH2, a key component of the Polycomb-Repressive Complex 2 upregulated in aggressive-variant prostate cancer, significantly enhances the efficacy of carboplatin chemotherapy by suppressing DNA repair pathways and promoting apoptosis, thereby overcoming the limitations of EZH2 inhibitors as monotherapy.

Latarani, M., Pucci, P., Eccleston, M. + 13 more2026-02-25📄 pharmacology and toxicology

Suppressing Bone Resorption and Promoting Mineralization with Tetracycline Derivatives

This study demonstrates that tetracycline derivatives, particularly doxycycline, exhibit a dose-dependent dual effect by inhibiting osteoclast-mediated bone resorption while promoting osteoblast proliferation and mineralization at low to moderate concentrations, suggesting their potential as dual-function therapies for osteoporosis.

Shimochi, S., Hrovat, K., Sarwer, U. + 11 more2026-02-25📄 pharmacology and toxicology

A Degron Decoy System Co-opts Pathological Seeding to Enable Clearance of Multimeric α-Synuclein.

This study introduces a degron decoy system that exploits the pathological seeding mechanism of alpha-synuclein to selectively target and degrade toxic multimeric aggregates while sparing functional monomers, offering a novel therapeutic strategy for proteinopathies that does not require specific small-molecule binders.

Gadbois, G. E., Plonski, A., Debelouchina, G. + 1 more2026-02-24📄 pharmacology and toxicology

Exploring the Influence of Chemical Exposures in Breast Cancer Disparities: High-Throughput Transcriptomic Analysis in Normal Breast Cells from Diverse Donors

This study utilizes high-throughput transcriptomic profiling of normal breast cells from diverse donors to demonstrate that exposure to specific environmental chemicals, particularly those with documented racial disparities, induces biological changes linked to aggressive breast cancer hallmarks, such as cell cycle dysregulation and altered cellular plasticity, at concentrations relevant to the US population.

Zhao, N., Zhao, P., Tapaswi, A. + 8 more2026-02-24📄 pharmacology and toxicology

Single-cell transcriptomics reveals a differential response of human bronchial epithelial cell-types to cadmium chloride

This study demonstrates that single-cell transcriptomics reveals cell type-specific responses to cadmium chloride in human bronchial epithelial cells, uncovering distinct detoxification patterns across different cell types that are masked in bulk analysis and offering high-resolution insights to refine Adverse Outcome Pathways in predictive toxicology.

Abou Choucha, F., Lopez-Goncalvez, R., Hermet, T. + 13 more2026-02-24📄 pharmacology and toxicology

Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells

This study demonstrates that a polypharmacy cocktail of four common drugs induces sublethal, concentration-dependent metabolic changes in mouse liver sinusoidal endothelial cells, specifically causing synergistic defenestration and altered endocytosis at first-pass concentrations, which underscores the need to account for combinatorial drug effects on liver endothelial function in safety assessments.

Gnanachandran, K., Spigseth Hovland, D., Pospisil, J. + 4 more2026-02-24📄 pharmacology and toxicology

Turmeric Phyto-NanoParticle (TPNP) enhances cellular bioavailability and anti-inflammatory effect of curcuminoids in human monocytes / macrophages

This study demonstrates that a novel, additive-free Turmeric Phyto-NanoParticle (TPNP) formulation significantly enhances the cellular bioavailability, antioxidant capacity, and anti-inflammatory efficacy of curcuminoids in human monocytes and macrophages compared to conventional delivery systems.

Habiyambere, B. C., Ghosh, A., D Souza, K. + 5 more2026-02-23📄 pharmacology and toxicology

Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals

This study establishes a standardized, medium-throughput automated behavioral screening framework using two planarian species (*Dugesia japonica* and *Girardia dorotocephala*) that effectively detects seizure-like behaviors induced by known mammalian seizurogenic chemicals and specific pesticides, offering a cost-effective alternative to traditional mammalian testing.

Ireland, D., Coffinas, E., Rabeler, C. + 1 more2026-02-23📄 pharmacology and toxicology

Discovery and Optimization of Small Molecule Inhibitors of the SLIT2/ROBO1 Protein-Protein Interaction Using DNA-Encoded Libraries

This study reports the discovery and optimization of potent small-molecule inhibitors targeting the challenging SLIT2/ROBO1 protein-protein interaction through a DNA-encoded library screen, followed by rational design and fragment-based deconstruction to yield a minimal azaindole pharmacophore with significantly improved binding affinity and functional potency.

Garcia-Vazquez, N., Yuan, S., Gabr, M.2026-02-23📄 pharmacology and toxicology

Subchronic Toxicity Study of Nitric Oxide Nano Bubbles Injection in Sprague-Dawley Rats

A 90-day subchronic toxicity study in Sprague-Dawley rats demonstrated that intravenous administration of nitric oxide nanobubbles at doses up to 0.06 mL is generally safe, showing no mortality and only mild to moderate histological changes in the liver, kidney, and spleen, thereby supporting further formulation optimization for potential human clinical trials.

Novrial, D., Inayati, N. S., Gumilas, N. S. A. + 2 more2026-02-21📄 pharmacology and toxicology

Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

This study demonstrates that chronic exposure to a mixture of four common pesticides disrupts hepatic metabolism and exacerbates diet-induced glucose intolerance and insulin resistance in mice, highlighting that nutritional status significantly influences the metabolic risks associated with environmental pesticide exposure.

Rives, C., Poirier-Jaouen, N., Martin, C. M. P. + 25 more2026-02-21📄 pharmacology and toxicology

A metabolically resistant spexin analogue, LIT-01-144, induces potent non-opioid peripheral antinociception in persistent pain via activation of GALR2

This study reports that LIT-01-144, a metabolically stable spexin analogue that selectively activates GALR2, induces potent non-opioid peripheral antinociception in persistent inflammatory pain without crossing the blood-brain barrier, highlighting GALR2 as a promising target for novel analgesic therapies.

Berthome, Y., Le Coz, G.-M., Utard, V. + 14 more2026-02-20📄 pharmacology and toxicology

Potassium-Selective Nanoelectrode Arrays for Single-Cell Profiling of human iPSC-Derived Cardiomyocytes

The paper introduces KINESIS, a novel nanofabricated platform utilizing valinomycin-coated nanopillars to enable label-free, subcellular-resolution, and chemically specific monitoring of potassium dynamics in human iPSC-derived cardiomyocytes, overcoming the limitations of existing electrophysiological tools for cardiac disease modeling and drug screening.

Meganathan, D. P., Banzon, R., Casanova, A. + 10 more2026-02-18📄 pharmacology and toxicology